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[15] For kidney stone prevention, NICE guidance (NG118) recommends increasing fluid intake to achieve a urine output of at least 22.5 litres per day, reducing dietary salt (to less than 6 grams per day), and moderating animal protein intake

Both forms work identically and share the same mechanism of action

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Organ growth concerns (acromegaly-like effects) are theoretically possible with chronic supraphysiological IGF-1 exposure, though no human studies document this outcome at research doses below 100 mcg daily for fewer than 12 weeks

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