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Another melanocortin agonist, melanotan II (MT-2), has also been reported as helpful in improving ED in men with either psychological or organic ED

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Similarly, 5-methoxytryptophan (5-MTP) inhibits fibroblast-to-myofibroblast transition and ECM protein expression by downregulating TGF-/Smad3 and PI3K/AKT pathways, thereby limiting fibroblast proliferation and migration [113]