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Sources reviewed include the official Vital Blood product website (thevitalblood.com), the brand's Terms of Service and published FAQ, the brand's Supplement Facts panel as documented in official product materials, and peer-reviewed literature on L-Arginine, L-Citrulline, and blood pressure from PubMed and PMC (National Library of Medicine), including a 2019 systematic review in Nutrients on oral L-Arginine and L-Citrulline supplementation, a 2022 systematic review and meta-analysis in Advances in Nutrition, and a 2024 assessment of registered clinical trial designs published in Pharmaceuticals

This property stems from their hydrophilic nature, which minimizes protein adsorption and immune system recognition, allowing POx-coated nanoparticles to circulate without significant complement activation or antibody production

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