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Peron JPS, Nakaya H (2020) Susceptibility of the elderly to SARS-COV-2 infection: ACE-2 overexpression, shedding, and antibody-dependent enhancement (ADE)

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Pre-treatment of HGF with trisulfides and nitration Recombinant mouse HGF (carrier protein-free) was pre-treated with glutathione trisulfide (GSSSG) and lipoic acid trisulfide (LASSS) at mole ratios (HGF : trisulfide) of 1:0 (with solvent alone), 1:400, 1:1000, and 1:4000 at pH 7.4, 25C just prior to the peroxynitrite protocol (optimized at a molar ratio 1:2000 relative to HGF, pH 7.4, 37, for 30 min), which was previously demonstrated to induce maximal nitration of Y198 and Y250 located in the -chain under physiological conditions as described previously 32

Mechanistically, ammonium disrupts acidic compartments, as indicated by reduced LysoTracker staining, likely impairing the pH-dependent maturation of perforin (79)

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So it would follow that an effective weight-loss drug like GLP-1s would have a benefit for obese patients with arthritis