In oncology, there's potential for it to target senescent cells within the tumor microenvironment, possibly impeding cancer progression and metastasis
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partial sequence of human Body Protection Compound Sequence: H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH (GEPPPGKPADDAGLV) Synonyms: PL 14736, PLD-116 CAS Number: 137525-51-0 Molecular Formula: C 62 H 98 N 16 O 22 Molecular Weight: 1419.55 g/mol Mechanism (working): modulation of nitric oxide system, VEGFR-2 expression, and growth factor signaling supporting GI, vascular, and connective-tissue repair Regulatory status: not approved by the FDA or EMA TB-500 Compound class: synthetic N-acetylated heptapeptide
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A substantial proportion of these compounds are lipophilic in nature and exhibit extremely low solubility in the aqueous environment of the gastrointestinal tract
A., Rytlewska, M., Jasklska, M., & Chmielewski, M
