It was the difference between losing mostly fat and losing a concerning amount of muscle
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For patients with a BMI well above 35, or with severe obesity-related complications, that extra magnitude can matter clinically, not just cosmetically
Conclusions Skeletal muscle wasting is a frequent and clinically significant complication in patients with T2D and obesity, which is exacerbated by chronic inflammation, insulin resistance and metabolic dysregulation
After switching from sitagliptin to tirzepatide, glycemic control rapidly improved, but the patient felt haziness with distortion of the central part of the left eye
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