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More serious but less common risks include pancreatitis, gallbladder issues, and dehydration-related complications

This variability could affect the comparability of AE incidences between different GLP-1RAs

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In summary, the composition of BAs in T2DM patients requires further analysis through additional clinical studies that consider relevant factors such as age, sex, geographic location, the use of bile acid drugs (e.g., metformin), and metabolic surgery [19, 35, 36]

In addition, berberine can aggravate the cytotoxicity induced by 6-OHDA in PC12 cells and aggravate of dopaminergic neuron death (Kwon et al., 2010)