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It has been demonstrated that, although MASH drives disease progression, fibrosis is the most critical predictor of prognosis, in terms of both liver disease and overall mortality

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While the relevance to humans is unclear, these drugs carry a black box warning and are contraindicated in patients with a personal or family history of MTC or MEN 2

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doi: 10.3390/ijms241512032 27 XiaoSQiMZhouQGongHWeiDWangGet al

Surg Obes Relat Dis 18(3):373383 [DOI] [PubMed] [Google Scholar] 37.Schafer AL, Kazakia GJ, Vittinghoff E et al (2018) Effects of gastric bypass surgery on bone mass and microarchitecture occur early and particularly impact postmenopausal women: bone mass and microarchitecture after gastric bypass surgery