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The Non-Peptide GLP-1 Receptor Agonist WB4-24 Blocks Inflammatory Nociception by Stimulating -Endorphin Release From Spinal Microglia

Scher JU, Ogdie A, Merola JF, Ritchlin C

Ozempic and Wegovy, made by Novo Nordisk, mimic the effects of GLP-1, a type of hormone in the body that impacts everything from the brain to muscle to the pancreas, stomach and liver, according to the National Institutes of Health

Exendin-4 administration reduced visceral hypersensitivity in a dose-dependent manner and decreased serotonin levels in the colon

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It takes another 7 years (approximately) for such cells to develop subclones with metastatic capacity and another 3 years (approximately) before the disease will be diagnosed due to clinical symptoms and a clinically apparent primary tumor accompanied by metastases (13)