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Excess adipose tissue (as occurs when people are overweight) is linked to insulin resistance so weight loss is helpful in the treatment of T2DM

10.1016/j.actbio.2023.05.025 112 LiuS.FangY.YuJ.ChangX

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Though most people with type 2 diabetes are offered metformin as a first-line treatment, your healthcare provider will consider your entire health profile in recommending additional drug therapies