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Regional cardiovascular-mortality data further underline the urgency of therapies that simultaneously address glycemia, weight, and cardiometabolic risk
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Common clinical findings in these cases include: Persistent nausea and early satiety lasting weeks or months after discontinuation of the drug
--- 5 Dosage Initial dose: 5 mg once daily (usually at bedtime) After 46 weeks Increase to 10 mg daily Severe cases: up to 23 mg daily (extended-release form) --- 6 Adverse Effects Common: Nausea Vomiting Diarrhea Insomnia Muscle cramps Fatigue Serious: Bradycardia Syncope GI bleeding QT prolongation (rare) Due to increased cholinergic activity
Changes in blood pressure: Both elevation and reduction have been noted
Table Gastric Pentadecapeptide BPC 157, Roberts Stomachcytoprotection/adaptive Cytoprotection/organoprotection, and Selyes Stress Copingresponse: Progress, Achievements, and the Future, Gut Liver , 14, 153167
