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There's no strong evidence of receptor desensitization with continuous use, but periodic breaks remain standard practice in most clinical protocols

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Preclinical studies in mice demonstrate significant reductions in fat mass and body weight without changes in food intake

[DOI] [PubMed] [Google Scholar] 49.Ilic S, Drmic D, Zarkovic K, Kolenc D, Coric M, Brcic L, Klicek R, Radic B, Sever M, Djuzel V, Ivica M, Boban Blagaic A, Zoricic Z, Anic T, Zoricic I, Djidic S, Romic Z, Seiwerth S, Sikiric P

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