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This synthetic peptide is quietly redefining how we think about multi-pathway longevity therapeutics

De novo synthesis of serine from the glycolytic intermediate 3-phosphoglycerate (3-PG) occurs through a pathway consisting of three sequential steps: phosphoglycerate dehydrogenase (PHGDH) oxidizes 3-PG to 3-phosphohydroxypyruvate (pPYR) using an NAD + cofactor, phosphoserine aminotransferase (PSAT) transaminates pPYR to phosphoserine (pSER) using glutamate as the nitrogen donor, and finally phosphoserine phosphatase (PSPH) dephosphorylates pSER to produce serine [68]

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One of its most notable characteristics is its influence on gene expression

While C and S drive weight loss by reducing energy intake (EI) 11,14,15 , it is less clear whether they also affect energy expenditure (EE)

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