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Heres what a U-shaped curve looks like (data points are invented for illustration purposes): Photo by Innerbody Research In this invented example, the intervention in question does its best job at reducing a negative biomarker at around 200mg, after which the effect tapers off and soon becomes almost nonexistent

A cofactor is a mineral (or other helper molecule) required for an enzymes structure or catalytic activitywithout it, the enzyme may be present but functionally limited