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In individuals with obesity, adipose tissue becomes a source of inflammation, producing higher levels of proinflammatory markers like tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and monocyte chemotactic protein-1 [22]

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The patient selection window spanned from 1 August 2020 to 31 December 2021 to include the earliest market launch dates of the dulaglutide higher doses and of oral semaglutide (January 2021 and August 2020, respectively)

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