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In murine models of allergic airway inflammation, melatonin reduced eosinophilia, type 2 cytokine production, and airway hyperreactivity without altering ILC2 abundance

Clin Gastroenterol Hepatol 2019;17:748-755 e3

Over time, there are also potential concerns to consider: Skin thinning (atrophy) with prolonged use Worsening of symptoms after stopping treatment In some cases, a condition called topical steroid withdrawal , which may involve burning, stinging, or rebound flares after discontinuation Not everyone experiences these issues

Dorostghoal M, Seyyednejad SM, Nejad MNT

The clinical trial participants were on controlled diets