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The synthesis of mitochondrial membrane, mtDNA replication, transcription, translation, and the synthesis and import of mitochondrial proteins encoded by nuclear DNA are important factors in the process of mitochondrial biogenesis (Golpich et al., 2017

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Osteoarthritis (rabbit model) Experimental Design: Animal: New Zealand white rabbit, collagenase induced knee osteoarthritis model

Notably, the requirement for INTS12-mediated Pol II removal is context dependent, as it is not advantageous during the transcription-coupled response to formaldehyde-induced DNAprotein crosslinks, which rely on a distinct proteasome-dependent degradation pathway

Data are shown as the mean s.e.m