The recombinant purified form of IDE showed no glutathionylation
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Because this process happens at a cellular level over several weeks or months, some protocols suggest higher doses to ensure enough glutathione reaches the skin cells
In liver-focused contexts, combinations have been studied, including S-acetyl-glutathione paired with silybin in dogs with liver disease (Martello, 2023)
Additionally, NAC supplementation has been found to significantly increase glutathione (GSH) levels in follicular fluid [59]