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In 2009, the FDA imposed stronger language, requiring all over-the-counter acetaminophen products to warn that overdosing may cause severe liver damage. The FDAs wording was nearly identical to what its expert panel had recommended 32 years earlier

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This dysregulation may have downstream effects on the gut microbiome, which is known to exhibit high levels of dysbiosis in ME/CFS patients (Morten et al., 2018