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SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice

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Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection in the elderly, and it may be useful to assess renal function in these patients prior to initiating dosing and periodically thereafter [see Dosage and Administration

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Recent findings from studies on humans and animals demonstrate that GLP-1R agonists can also modulate the stress response via HPA axis activation but data obtained so far are ambiguous