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Cancer Cell 10 , 5164 (2006)

When methylation is insufficient: Histamine breakdown slows Histamine accumulates in the brain Serotonin and dopamine signaling becomes dysregulated Patients with undermethylation and high histamine often exhibit: Depression with anxiety or irritability OCD tendencies or rigid thinking Seasonal worsening of symptoms Sensitivity to folate or methyl donors if used incorrectly Does SAMe or methionine help

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Signal Transduction and Targeted Therapy , 7 (1), 216.