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Steroid Biochemistry & Molecular Biology, 212, 105876

Purine metabolism, ABC transporters, Renin secretion, FoxO signaling pathway, AminoacyltRNA biosynthesis, and cGMPPKG signaling pathway were the major metabolism pathways disturbed in obese mice

We previously showed that oral intake of long-term oscillating glucose (LOsG, 4 times/day for 38 days) can lead to -cells gaining metabolic memory in reactive oxygen species (ROS) stress, inhibition of insulin and SOD-2 expression, and the development of prediabetes with hypoinsulinemia and glucose intolerance [3]

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