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Provides testing ground for therapies eventually translating to human use
Unscheduled DNA synthesis, induced by the N -acetoxy-2-acetylamino- fluorene, was inhibited by ethylene oxide in human lymphocytes in vitro (Pero et al., 1981)
K.GretherJ.HansenR.et al
There is also the matter of political influenced by large pharmaceutical companies who are seeking to control production, patent these compounds, and sell them at much higher prices
To overcome these limitations, future studies should focus on refining organoid coculture systems, integrating tumor-immune components, and developing short-term dynamic models that preserve cellular heterogeneity and better simulate in vivo conditions
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