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N Engl J Med 2025;392:1569-81

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Improved flexibility : The peptide aids in restoring flexibility and mobility in injured areas, enhancing overall function

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Immunofluorescence staining also showed a marked increase in the number of Ki-67-positive cells and a decrease in the nuclear content of -H2AX and P21 after FOXO4-DRI treatment (Figures 4B,C)

For peptides that work systemically like growth hormone secretagogues that act on the pituitary, or repair peptides like BPC-157 that work through systemic circulation this is the only delivery method that reliably produces the expected effect