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455 Solanezumab ( 18 , LY2062430) is an antibody targeting the intermediate domain of A, effective against soluble, monomeric, non-fibrillar forms of A, thus promoting the dissolution of plaques

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Ding, W

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Subsequently, this triggers further ROS production and reactivates the inflammatory cycle, exacerbating apoptosis in corneal and conjunctival epithelial cellsa process that perpetuates a vicious circle causing the progression of DED ( A significant link exists between oxidative stress, systemic diseases, and DED