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NTS has reciprocal direct or indirect projections to several higher CNS centers, including the parabrachial nucleus, hypothalamus, limbic system and forebrain providing the neuroanatomical substrate for the integration of various sensory, affective and emotional responses to nausea and vomiting ( CVS is viewed as a final common phenotype driven by synergistic interaction of discrete pathophysiological pathways

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doi: 10.1016/0006-2952(92)90725-X 149 SugiharaKNakanoSKodaMTanakaKFukuishiNGembaM

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Its more or less the scenario my colleague Ariana and I had talked about in anticipation of the impasse in Washington