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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Collins JK, Davis AR, Adams A, Perkins-Veazie P

In contrast to PD-L1-mediated T-cell dysfunction induced by glutamine limitation, DON and its prodrug JHU-083 skew CD8(+) T cells toward a highly activated, persistent, and proliferative phenotype, thereby facilitating immunogenic cancer cell death 58,149,150 (Fig