Effect of water stress on the chloroplast antioxidant system
Treatment decisions must be made on the basis of clinical history and signs and symptoms of cyanide intoxication
MakJCHoSPHoASLawBKCheungAHHoJCet alSustained elevation of systemic oxidative stress and inflammation in exacerbation and remission of asthma
Sm., an ethnomedicinal plant, in arthritic animals
Assessment of the morphology of LS loaded nanospanlastics A transmission electron microscope (TEM) (JEOL 100 CX II, Tokyo, Japan) was used to examine the morphology of the chosen LS nanoformulation
event-driven endpoint Obstructive Sleep Apnea Status: Phase 3 Planned Focus: OSA severity reduction (apnea-hypopnea index) with CagriSema-induced weight loss Population: Adults with moderate-severe OSA and obesity Timeline: Expected enrollment 2024-2025 NASH/MAFLD Status: Phase 2 Ongoing Focus: Hepatic steatosis, inflammation, and fibrosis improvement Population: Adults with biopsy-confirmed NASH/MAFLD Timeline: Results expected 2025 Heart Failure with Preserved EF Status: Preclinical Planning Focus: HFpEF outcomes in obese patients following substantial weight loss Rationale: Obesity-HFpEF phenotype may benefit from profound weight reduction Timeline: Early development phase Pediatric Obesity Status: Phase 2 Planning Focus: Safety, tolerability, and efficacy in adolescents (12-18 years) Population: Adolescents with obesity (BMI 95th percentile) Timeline: Expected initiation 2025 Oral Formulation Development Status: Preclinical Focus: Oral bioavailability enhancement for cagrilintide using absorption enhancers Rationale: Oral delivery could improve accessibility and adherence Timeline: Research phase
