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SURPASS-1 shows that tirzepatide alone, at all doses, was superior to placebo and revealed a dose-dependent reduction of HbA1c by up to 2.07% (p 10% weight loss can be disease modifying and may even lead to disease remission [38]

Potential under-treatment can lead to frustration or stalled progress

Disruption of insulin signaling is directly related to the activation of mechanisms involved in the progression of the neurodegenerative process