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in HFpEF, the prevalence of obesity reaches up to 80%

As examined in Designed to Kill: Who Profits from Paraquat?, manufacturers have promoted paraquat as indispensable, discouraging alternatives and reinforcing overuse

Beyond those primary effects, berberine has shown favorable results on inflammatory markers including CRP and IL-6, and emerging research points to gut microbiome benefits berberine appears to shift bacterial composition toward strains associated with metabolic health

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Cardiovascular-Kidney-Metabolic (CKM) Syndrome , as defined by the AHA, is a systemic disorder characterized by pathophysiological interactions among metabolic risk factors (such as obesity, insulin resistance, dyslipidemia, and hypertension), chronic kidney disease (CKD), and the cardiovascular system, leading to multiorgan dysfunction and a high rate of adverse cardiovascular outcomes [145]