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Psychiatry 83 , 437440 (2012)
Ropivacaine treatment significantly upregulates the LC3-II/LC3-I ratio and the levels of Beclin1, PINK1, and Parkin proteins in rat PC12 cells and hippocampal neuronal cells (HT22), decreases the expression of p62, TOM20, and COXIV proteins, promotes mitochondrial hyperautophagy, increases the expression of pro-apoptotic proteins Bax and cleaved-caspase-3, decreases the expression of anti-apoptotic protein Bcl-2, reduces mitochondrial MMP, increases ROS, and induces apoptosis in PC12 and HT22 cells
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Medication/Drugs Mixing alcohol and medications/drugs together can lead to serious physical, behavioral, and health complications
10.1016/j.mce.2007.10.007 34 VroniqueR.PatrickL.StphaneL
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