Over the past few years, we have seen the vital roles the metal nanomedicines play in the GSH-responsive and -exhausting strategies, and inorganic nanomaterials, MOFs, and platinum-based nanomaterials-mediated GSH depletion is expected to realize more powerful synergistic therapy based on rational design
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Unlike exogenous testosterone replacement, which suppresses the hypothalamic-pituitary-gonadal axis and can impair fertility, tirzepatide works by restoring the natural production pathway
4 Current therapeutic landscape and unmet need While resmetirom (a THR- agonist) has recently gained FDA approval for the treatment of MASH (in patients with fibrosis F2-F3), marking the first-ever pharmacological agent for this condition (Liu et al., 2025), there remains no single FDA-approved drug that effectively prevents or reverses the progression of advanced SLD to HCC
Under him, Pfizer developed blockbusters like Eliquis and Prevnar
A meta-analysis of the evidence
