fda glp-1 news november 2025 ISPOR 2025: Exploring reasons for discontinuation GLP-1 receptor agonists and next-generation

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Fielding, R., Riede, L., Lugo, J., & Bellamine, A

Mechanism in research literature NNMT (nicotinamide N-methyltransferase) catalyses the methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine

In my recent Pharmaceutical Executive article, I explore why this diagnostic gap persists and the clinical importance of improving earlier and more accurate classification, including broader use of tools such as autoantibody and C-peptide testing

Caetano BDL

The same pigments that make fruits and vegetables vibrant (like the orange in carrots or the deep green in spinach) often indicate eye-supporting nutrients