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However, given the retrospective design and 6-month follow-up, larger prospective studies with longer observation periods are required to confirm the durability and long-term clinical implications of these findings

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166 Because a low-FODMAP diet can negatively affect the gut microbiome, reintroducing foods high in prebiotic fibers, while maintaining symptom control, is an important goal

Women who were pregnant, lactating, or had not adhered to adequate contraception from at least 30 days prior to the study entry and did not plan to for 1 month after the final supplementation were also excluded

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The method of any one of embodiments 23-33, wherein the gel comprises a copolymer of polyoxyethylene and polyoxypropylene