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Key Comparability Parameters Evaluated by LC-MS Molecular weight consistency Sequence identity Impurity profiles Degradation patterns Post-translational modifications Comparative LC-MS studies have shown that manufacturing processes can influence impurity profiles and degradation behavior

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The membranes were imaged using Typhoon 5 imaging system (Amersham)

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doi:10.1124/jpet.108.149211 Raun K, Hansen BS, Johansen NL, et al

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