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In patients with type 2 diabetes, semaglutide drugs work as GLP-1 receptor agonists, helping them stabilise insulin levels and keep them feeling full for longer
Its a harsh reality, but its the truth
This may unintentionally exaggerate perceived effectiveness
In more disease-relevant -synuclein models (A53T transgenic and preformed fibril mice), PEGylated exendin-4 (NLY01, a modified form of exenatide) improved survival, motor behavior, and pathology (149)
Furthermore, advanced drug-delivery systems, including nanoparticle formulations, ROS-responsive hydrogels, thermo-sensitive polymers, and sustained-release microspheres, are also rapidly evolving
Pulling data from 19 randomised controlled trials, a 2024 systematic review and meta-analysis found that psyllium is not just useful as a digestive supplement, but also has some metabolic benefits, too
