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SGLT2 inhibitors, such as empagliflozin and canagliflozin, have similar A1C-lowering properties (0.5%-0.8%) and out-of-pocket costs (except for alogliptin, which is available generically), but have the added advantages of CV risk reduction, BP-lowering, and weight loss

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The resulting IC 50 values summarized in Table 1 were used to orient our experiments and give the reader an impression of the pharmacological range in which the experiments took place