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A well-known originator of ER stress is the gathering of faulty proteins, whose levels rise as a consequence of unsuitable protein folding, insufficient protein degradation or dysfunction of the ER

274,276 This indicates that Trx regulates the MMP/TIMP balance by differentially inhibiting the activities of TIMP and MMP, and this process depends on the redox active sites of Trx and TrxR

The 16S data was tested for normality and alpha-diversity metrics were statistically compared using multiple unpaired t-tests, corrected for multiple comparisons using the HolmSidak method (GraphPad Software Inc., La Jolla, CA)

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