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Additional safety considerations include risk of dehydration and acute kidney injury, potential worsening of diabetic retinopathy with rapid glucose improvement (particularly with semaglutide), and hypoglycemia risk when combined with insulin or sulfonylureas

High-fat foods High-fat foods such as fried foods, fatty meats, and rich desserts can make digestive issues like nausea, diarrhea, and constipation worse

Understanding Semaglutide: A Key to Weight Loss and Liver Health Slim Transformation Nov 20, 2025 4 min read Updated: Dec 3, 2025 What Is Semaglutide and How Is It Used

bioRxiv, 2024.06

From Diabetes Treatment to Weight Loss Originating as a groundbreaking treatment for type 2 diabetes, GLP-1 medication has recently emerged as a promising solution for those struggling with obesity and excess weight

Graham MR, Ryan P, Baker JS, Davies B, Thomas NE, Cooper SM, Evans P, Easmon S, Walker CJ, Cowan D, Kicman AT