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Water, Butylene Glycol, Caprylic/Capric Triglyceride, Propanediol, Cetearyl Alcohol, Hydrogenated Poly(C6-14 Olefin), Cetyl Ethylhexanoate, Polyglyceryl-3 Methylglucose Distearate, Niacinamide, Butyrospermum Parkii (Shea) Butter, Glyceryl Stearate, Macadamia Ternifolia Seed Oil, Vinyl Dimethicone, Cetearyl Olivate, Pentylene Glycol, Sorbitan Olivate, Phenoxyethanol, Beeswax, Arginine, Behenyl Alcohol, Carbomer, Polymethylsilsesquioxane, Hydrogenated Vegetable Oil, Sodium Polyacryloyldimethyl Taurate, Hydrogenated Polydecene, Ethylhexylglycerin, Glutathione, Stearic Acid, Sorbitan Isostearate, Xanthan Gum, Disodium EDTA, Trideceth-10, Glycine, Serine, Glutamic Acid, Aspartic Acid, Leucine, Alanine, Lysine, Tyrosine, Phenylalanine, Valine, Threonine, Proline, Isoleucine, Histidine, Methionine, Cysteine

What they found: Cagrilintide 4.5 mg: 10.8 % weight reduction vs 3.0 % placebo (p 40 % of patients achieved 25 % weight reduction , historically unprecedented Safety profile in line with Phase 2 data Why it matters: REDEFINE 1 confirmed CagriSema as the largest body-weight signal reported in the published incretin literature to date

Drug Categories Peptides

Premuzic Mestrovic I, Smoday IM, Kalogjera L, Krezic I, Zizek H, Vranes H, et al

The Glow Getter Body Oil Carthamus Tinctorius (Safflower) Seed Oil, Ricinus Communis (Castor) Seed Oil, Caprylic/Capric Triglyceride, Squalane, Hydrogenated Ethylhexyl Olivate, Cocos Nucifera (Coconut) Oil, Cocos Nucifera (Coconut) Fruit Extract, Simmondsia Chinensis (Jojoba) Seed Oil, Tetrahexyldecyl Ascorbate, Hippophae Rhamnoides Fruit/Seed Oil, Linoleic Acid, Phospholipids, Phytosterols, Rosa Canina Fruit Oil, Vanilla Planifolia Fruit Extract, Hydrogenated Olive Oil Unsaponifiables, Gamma-Decalactone, Benzotriazolyl Dodecyl P-Cresol, Gamma-Nonalactone, Delta-Decalactone, Delta Dodecalactone, Gamma-Dodecalactone, Gamma-Undecalactone, Gamma-Nonalactone, Limonene

10.1152/ajpendo.00492.2002 169 Jian-LiangZ.Yong-WenQ.XingZ.Jian-LiQ.JiangC.Rong-LiangX