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[2] In SURPASS-1, Mounjaro (15 mg) demonstrated a mean weight reduction of 22.5% compared to 3.0% with placebo at 52 weeks

All subjects in PIONEER 5 had chronic kidney disease (CKD, estimated glomerular filtration rate [eGFR] 3059 mL/min/1.73 m 2 only)

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Additionally, leptin expression in adipose tissue was suppressed, thereby inhibiting inflammatory responses in adipocytes via multiple regulatory mechanisms [97]

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