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2b, d, f) and, more importantly, our molecular dynamics (MD) study (Fig

Short-term, supra-physiological rhGH administration induces transient DNA damage in peripheral lymphocytes of healthy women

External links [edit] Media related to Lentigo maligna at Wikimedia Commons

HGHs anabolic effects are mediated primarily through IGF-1, which then acts on peripheral tissues such as muscle and bone. Laron, Z., Pediatric Endocrinology Reviews IGF-1 LR3: Direct Muscle Growth Stimulator IGF-1 LR3 binds directly to IGF-1 receptors on muscle fibers, triggering: Muscle cell differentiation and proliferation Activation of satellite cells , essential for muscle repair and new muscle fiber growth Enhanced nutrient uptake (glucose, amino acids, creatine) Because of this direct action , IGF-1 LR3 can stimulate local muscle hypertrophy without relying on systemic conversion pathways

doi: 10.1016/j.it.2025.08.003

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