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4.1 Acute liver failure ALF is an intractable clinical syndrome with multiple causes featured by a fast reduction in hepatic function, increased aminotransferases, altered mentation, and disturbed coagulation in the absence of chronic liver diseases

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Treatment was initiated in mice when they displayed clinical signs characteristic of intestinal tumour burden as defined in the relevant licensing documents (for example, hunching, bloody stools)

doi: 10.1124/jpet.109.162651

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