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This rate reflects the appetite-suppressing and metabolic effects of GLP-1 receptor agonists, which slow gastric emptying and increase satiety signals to the brain

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Clinical trials show participants lost 5-15% of baseline body weight over 68 weeks, though individual outcomes vary significantly based on genetics, biomarkers, and adherence

doi: 10.1016/j.bcp.2018.01.040 31 CampbellJEBeaudryJLSvendsenBBaggioLLGordonANUssherJRet al