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Progressive thyroid cell damage can change the apparent clinical picture from goitrous hypothyroidism to that of primary hypothyroidism, or "atrophic" thyroiditis

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doi:10.1080/21505594.2024.2399983 84

In studies on Achilles tendon tendinopathy in mice, it was observed that aged tendons exhibited elevated expression of inflammationrelated biomarkers, including inflammatory disulfide HMGB1, macrophage marker CD68, and senescenceassociated markers such as SAgal, p53, and p16 [63]