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Results do not disappear during off-cycles IGF-1 gradually returns to baseline over 2-4 weeks but the enhanced GH secretion depends on continued use

82 In type 2 diabetes-associated cognitive impairment animal models and high-glucose in vitro studies, neuroinflammatory markers, such as IL-1 , TNF-, IL-6, and MCP-1, and inflammatory responses, such as toll-like receptor 4, cyclooxygenase 1 (COX1), COX2, NF-B, leukocyte common antigen, and inducible nitric oxide synthase were increased in the brain

Lee, Sang-Ah, et al