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To empirically test this future hypothesis, long-term controlled trials may need to standardize the intervention by assigning either a probiotic or prebiotic regimen aimed at propionate enhancement to subjects with mild cognitive impairment

The different CRP isoforms, nCRP, non-native pentameric CRP (nnCRP) and mCRP (175178, 181184), may explain their protective and destructive effects, with nCRP being primarily antiinflammatory inducing Th2/M2 responses, while mCRP being typically proinflammatory inducing Th1/M1 responses (170, 185189)

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