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[2] In DIO mice, 5-Amino-1MQ was reported to reduce body weight and white adipose mass and to lower plasma cholesterol, without a measured change in food intake

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Additionally, a milder decrease in Complex II was observed in one patient [59]

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Notably, although TRFS-green exhibits detectable responses beyond TrxR in cell-free assays 28 , its fluorescence is markedly diminished in TrxR1-KO HCT116 cells