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Thus, in tumor angiogenesis, CUL5 forms a multidimensional regulatory network: it enhances pro-angiogenic signals via the TRAF6/NF-B/HIF-1/VEGF axis while simultaneously suppressing the MAPK/PI3K-AKT pathway through Visfatin degradation, balancing HIF stability and MAPK phosphorylation
doi: 10.1007/s11010-022-04564-4 21 DavidL