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First-line treatment typically involves: Methotrexate the most commonly prescribed conventional synthetic DMARD Sulfasalazine or hydroxychloroquine alternative or combination options Leflunomide for patients who cannot tolerate methotrexate These medications are usually combined with short-term corticosteroids (such as prednisolone) to provide rapid symptom relief whilst DMARDs take effect, which can take several weeks to months

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Water intake also supports normal metabolic and digestive processes

Recognizing the Signs of Melasma Melasma typically presents as dark, irregularly shaped patches on sun-exposed areas of the skin

However, the side effects profile mainly depends on an individuals tolerance, body metabolism, genetics, lifestyle habits, and health conditions

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